If you can create it, Spot Process Separation Studio can separate it.
From photographs, scans, Photoshop® files, Corel Painter® files, highly modeled illustrations and more the BEST tonal image color separation software is Spot Process Separation Studio.™
Take a look below at the various art styles created using a wide variety of graphics applications and techniques - ALL separated using the Spot Process engine. All of these separations have been screen-printed on either manual or automatic presses with great success by screen-printers with various skill levels. More than a great separation engine for the pre-press department - this is a tried and true press production solution.
Buying the Separation Studio Software and AccuRip was definitely a big expense, but knowing how great the customer support is, and the quality of the software, I know it was worth it.
— Tristan, A Mystery in Common